Structure of DNA helicase

Helicases separates two strands of nucleic acid into their corresponding single chain. This process uses energy derived from hydrolysis of ATP. This video explains the structure of a viral helicases. Edited by Ashraf Many cellular processes (DNA replication, RNA transcription, DNA recombination, DNA repair, Ribosome biogenesis) involve the separation of nucleic acid strands. Helicases are often utilized to separate strands of a DNA double helix or a self-annealed RNA molecule using the energy from ATP or GTP hydrolysis. They move incrementally along one nucleic acid strand of the duplex with a directionality specific to each particular enzyme. There are many helicases (14 confirmed in E. coli, 24 in human cells) resulting from the great variety of processes in which strand separation must be catalyzed.[citation needed] Helicases adopt different structures and oligomerization states. Whereas DnaB-like helicases unwind DNA as donut shaped hexamers, other enzymes have been shown to be active as monomers or dimers. Their precise mechanisms of action remain unclear. Text Reff: http://en.wikipedia.org/wiki/Helicase

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Channels: Molecular Biology

Tags: DNA helicase replication enzimes

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Duration: 1m 43s

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