15835 views

Gleevecs mechanism of Action

The animation begins by introducing the Philadelphia Chromosome, the result of a reciprocal translocation between chromosomes 9 and 22. More specifically the breakpoint cluster region (BCR) of chromosome 22 is fused with part of the Abelson (ABL) gene on chromosome 9. The resulting BCR-ABL genetic domain now located within chromosome 22 and codes for a mutant tyrosine kinase also known as BCR-ABL. Under normal circumstances tyrosine kinase proteins respond to external cellular messaging proteins, and ultimately initiate a series of reactions that culminate in cellular replication. Conversely, BCR-ABL is constitutively active, meaning it does not require activation by the aforementioned cellular messaging proteins in order to stimulate cellular replication. This results in acceleration of cell division, an inhibition of DNA repair, overall genomic instability, and the fatal blast crisis characteristic of chronic myelogenous leukemia. The animation progresses to introduce Gleevec (imatinib), the first in a class of drugs that specifically target and competively inhibit the ATP binding site on BCR-ABL tyrosine kinase. This prevents the ABL domain from phosphorylating the tyrosine residue, and as a result preventing the proliferation of hematopoietic cells that express BCR-ABL. Therapy with imatinib results in a dramatic reduction of tumor clone cells and the occurrence of blast crisis', through targeted drug treatment which leaves health cells unscathed. Created by: Nelson Caetano Class of 2007 Pharmacy Dr. Bongsup Cho Professor of Biomedical and Pharmaceutical Sciences College of Pharmacy

You need to login to download this video.
login or signup

Channels: Scientific Animations Biochemistry Genetics

Tags: gleevec

Uploaded by: ( Send Message ) on 08-09-2007. Dnatube suggest users to have interest in drug testing, mesothelioma, insurance, medical lawyers.

Duration: 2m 26s

We promote science. You can find science videos on drug testing, mesothelioma, medical insurance and medical lawyers


Dnatube: Sciencific and Medical video site.