Bacteria communicate with chemical languages that allow them to synchronize their behavior and thereby act as multi-cellular organisms. This process, called quorum sensing, enables bacteria to do things they cant do as a single cell, like successfully infect and cause disease in humans. Bonnie Bassler, Ph.D., the Squibb Professor of Molecular Biology at Princeton University and President-elect for the American Society for Microbiology, has been researching strategies that can interfere with quorum sensing and will hopefully yield novel antibiotics to prevent disease. In this episode of MicrobeWorld Video we present the full presentation Dr. Bassler gave at the Marian Koshland Science Museum in Washington, D.C. on June 18, 2009. Not only does Dr. Bassler explain the mechanisms of bacterial communication, but she also puts forth her theories on how we can disrupt this communication for human benefit.