1558 views

Evolutionary tradeoffs and the geometry of gene expression

A short talk by Prof. Uri Alon. Watch the full length talk here: http://hstalks.com/?t=BL1893787 Topics Covered: Organisms, tissues and molecules often need to perform multiple tasks Usually no phenotype can be optimal at all tasks at once which leads to a fundamental tradeoff We study this using the concept of Pareto optimality from engineering and economics Tradeoffs lead to an unexpected simplicity in the range of optimal phenotypes; they fall on low dimensional shapes in trait space such as lines, triangles and tetrahedrons At the vertices of these polygons are phenotypes that specialize at a single task We demonstrate this using data from animal and fossil morphology, bacterial gene expression and other biological systems.

You need to login to download this video.
login or signup

Channels: Genetics Structural Biology Biomedical Engineering

Tags: gene expression evolutionary biology systems biology Pareto optimality phenotype uri alon tradeoff

Uploaded by: ( Send Message ) on 02-04-2015. Dnatube suggest users to have interest in drug testing, mesothelioma, insurance, medical lawyers.

Duration: 2m 29s

Dnatube: Sciencific and Medical video site.