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Evolutionary tradeoffs and the geometry of gene expression

A short talk by Prof. Uri Alon. Watch the full length talk here: http://hstalks.com/?t=BL1893787 Topics Covered: Organisms, tissues and molecules often need to perform multiple tasks Usually no phenotype can be optimal at all tasks at once which leads to a fundamental tradeoff We study this using the concept of Pareto optimality from engineering and economics Tradeoffs lead to an unexpected simplicity in the range of optimal phenotypes; they fall on low dimensional shapes in trait space such as lines, triangles and tetrahedrons At the vertices of these polygons are phenotypes that specialize at a single task We demonstrate this using data from animal and fossil morphology, bacterial gene expression and other biological systems.

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