A short talk by Prof. Uri Alon. Watch the full length talk here: http://hstalks.com/?t=BL1893787 Topics Covered: Organisms, tissues and molecules often need to perform multiple tasks Usually no phenotype can be optimal at all tasks at once which leads to a fundamental tradeoff We study this using the concept of Pareto optimality from engineering and economics Tradeoffs lead to an unexpected simplicity in the range of optimal phenotypes; they fall on low dimensional shapes in trait space such as lines, triangles and tetrahedrons At the vertices of these polygons are phenotypes that specialize at a single task We demonstrate this using data from animal and fossil morphology, bacterial gene expression and other biological systems.
Channels: Genetics Structural Biology Biomedical Engineering
Tags: gene expression evolutionary biology systems biology Pareto optimality phenotype uri alon tradeoff
Uploaded by: eyal.yaya ( Send Message ) on 02-04-2015.
Duration: 2m 29s