Replication of HCV

This video shows replication of HCV which involves several steps. The virus replicates mainly in the hepatocytes of the liver, where it is estimated that daily each infected cell produces approximately fifty virions (virus particles) with a calculated total of one trillion virions generated. The virus may also replicate in peripheral blood mononuclear cells, potentially accounting for the high levels of immunological disorders found in chronically infected HCV patients. HCV has a wide variety of genotypes and mutates rapidly due to a high error rate on the part of the virus' RNA-dependent RNA polymerase.

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Channels: Cell Biology

Tags: HCV

Uploaded by: ( Send Message ) on 04-05-2009.

Duration: 1m 20s