"Lec 12 - Biomolecular Engineering: General Concepts (cont.)" Frontiers of Biomedical Engineering (BENG 100) Professor Saltzman reviews the pharmacokinetic first-order rate equation that can be used to model changes in drug concentration in the blood, as well as its derivation from the law of conservation of mass. The importance of maintaining a drug concentration that is sufficient for therapeutic purpose, but below a toxic level, is emphasized. Since this is directly affected by drug administration method, ways to localize and sustain therapeutic concentrations of drug, such as incorporating in slow-releasing, biocompatible polymers are introduced. Professor Saltzman gave some examples of clinical applications of controlled release drug delivery system, such as anti-restenosis drug incorporated into stents, and chemotherapeutic drugs in brain implants and microspheres. 00:00 - Chapter 1. Model for Injected Drug Delivery 08:42 - Chapter 2. Model for Oral Drug Delivery 16:10 - Chapter 3. Drug as Implant: Potentials and Limits 38:46 - Chapter 4. Accessibility of New Drug Delivery Methods Complete course materials are available at the Open Yale Courses website: http://open.yale.edu/courses This course was recorded in Spring 2008.
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