"Lec 11 - Biomolecular Engineering: General Concepts" Frontiers of Biomedical Engineering (BENG 100) Professor Saltzman starts the lecture with an introduction to pharmacokinetics and pharmacodynamics. Professor Saltzman talks about the concept of dose-response. He introduces different routes of drug administration and how they affect drug distribution and bioavailability (i.e., intravenous, oral, and sublingual routes). First-pass drug metabolism by the liver is also identified as an important source of drug degradation. Finally, modeling the body as a well-stirred vessel, Professor Saltzman explains the first-order rate equation: C = (M0/V)*e-kt, that can be used calculate the amount of drug in the body (M) as a function of time (t) and a rate constant (k); and the equation for drug half-life: t = ln(2/k). 00:00 - Chapter 1. Introduction to Drug Delivery 07:13 - Chapter 2. Relationships Between Drug Dosage and Biological Response 12:21 - Chapter 3. Injections for Drug Delivery 28:47 - Chapter 4. Oral Drug Delivery 41:25 - Chapter 5. Drug Bioavailability Complete course materials are available at the Open Yale Courses website: http://open.yale.edu/courses This course was recorded in Spring 2008.
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Tags: bioavailability dose-response first-pass metabolism half-life pharmacodynamics pharmacokinetic modeling pharmacokinetics toxicology
Uploaded by: yalefrontbio ( Send Message ) on 31-08-2012.
Duration: 52m 49s
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Lec 1 - What Is Biomedical Engineering?
Lec 2 - What Is Biomedical Engineering? (cont.)
Lec 4 - Genetic Engineering (cont.)
Lec 5 - Cell Culture Engineering
Lec 6 - Cell Culture Engineering (cont.)
Lec 7 - Cell Communication and Immunology
Lec 8 - Cell Communication and Immunology (cont.)
Lec 9 - Biomolecular Engineering: Engineering of Immunity
Lec 10 - Biomolecular Engineering: Engineering of Immunity (cont.)
Lec 12 - Biomolecular Engineering: General Concepts (cont.)
Lec 13 - Cardiovascular Physiology
Lec 14 - Cardiovascular Physiology (cont.)
Lec 15 - Cardiovascular Physiology (cont.)
Lec 17 - Renal Physiology (cont.)
Lec 18 - Biomechanics and Orthopedics
Lec 19 - Biomechanics and Orthopedics (cont.)
Lec 23 - Tissue Engineering (cont.)
Lec 24 - Biomedical Engineers and Cancer