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DNA - acridine complex structure

DNA fragment complexed with acridine derivative (a carcinogenic dye). Data source: Protein Data Bank code 2GB9. Wiki text info: Acridine, C13H9N, is an organic compound and a nitrogen heterocycle. Acridine is also used to describe compounds containing the C13N tricycle. Acridine is structurally related to anthracene with one of the central CH groups is replaced by nitrogen. Acridine, a colorless solid, was first isolated from coal tar. It is a raw material used for the production of dyes and some valuable drugs. Many acridines also have antiseptic properties such as Proflavine. Acridine and related derivatives bind to DNA and RNA due to their abilities to intercalate. Acridine Orange (3,6-dimethylaminoacridine) is a nucleic acid-selective metachromatic stain useful for cell cycle determination.

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Channels: Scientific Animations Biochemistry Genetics

Tags: acridine

Uploaded by: ( Send Message ) on 18-09-2007.

Duration: 1m 5s