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    LexA DNA complex as regulator for SOS response

    This video describes LexA DNA complex. The SOS genes for DNA repair and cell division in bacteria are repressed by the binding of LexA repressor protein to the operator with SOS-box sequences under normal conditions. When they are challenged with sunlight UV, genotoxic chemicals etc., the LexA proteins are autocleaved with the help of RecA and single-stranded DNA, leading to the expression of the SOS genes to cope with DNA damage. The binding of LexA to the operator is carried out by the classical helix-turn-helix motif. This video is based on the recent refinement of the structure of the LexA-DNA complex (3JSO.pdb), in which the three alpha helices are colored pink-orange-blonde, beta strands are green-blue, and the gaps are for the disordered and flexible regions.

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