• 2507 views

    Lec 31 - Preparing Single Enantiomers and Conformational Energy

    "Lec 31 - Preparing Single Enantiomers and Conformational Energy" Freshman Organic Chemistry (CHEM 125) After mentioning some legal implications of chirality, the discussion of configuration concludes using esomeprazole as an example of three general methods for producing single enantiomers. Conformational isomerism is more subtle because isomers differ only by rotation about single bonds, which requires careful physico-chemical consideration of energies and their relation to equilibrium and rate constants. Conformations have their own notation and nomenclature. Curiously, the barrier to rotation about the C-C bond of ethane was established by measuring its heat capacity. 00:00 - Chapter 1. Introduction: Legal Implications of Chirality 03:36 - Chapter 2. Methods for Isolating Esomeprazole into a Single Enantiomer 15:14 - Chapter 3. Conformational Isomerism: An Introduction 31:36 - Chapter 4. Newman Projections and Nomenclature for Conformations 37:30 - Chapter 5. Understanding the Barrier to Rotate about the C-C Bond of Ethane Complete course materials are available at the Open Yale Courses website: http://open.yale.edu/courses This course was recorded in Fall 2008.

    Video is embedded from external source so embedding is not available.

    Video is embedded from external source so download is not available.

    Here is the next lecture for this course

    Watch NEXT
    LECTURE
    4611 views

    Lec 32 - Stereotopicity and Baeyer Strain Theory

     46:18
    Lecture List | Course Details | Contents | Related

    No content is added to this lecture.

    Go to course:

    This video is a part of a lecture series from of Yale

    Lecture list for this course

    Lec 1 - How Do You Know?

    Lec 2 - Force Laws, Lewis Structures and Resonance

    Lec 3 - Double Minima, Earnshaw's Theorem and Plum-Puddings

    Lec 4 - Coping with Smallness and Scanning Probe Microscopy

    Lec 5 - X-Ray Diffraction

    Lec 6 - Seeing Bonds by Electron Difference Density

    Lec 7 - Quantum Mechanical Kinetic Energy

    Lec 8 - One-Dimensional Wave Functions

    Lec 9 - Chladni Figures and One-Electron Atoms

    Lec 10 - Reality and the Orbital Approximation

    Lec 11 - Orbital Correction and Plum-Pudding Molecules

    Lec 12 - Overlap and Atom-Pair Bonds

    Lec 13 - Overlap and Energy-Match

    Lec 14 - Checking Hybridization Theory with XH_3

    Lec 15 - Chemical Reactivity: SOMO, HOMO, and LUMO

    Lec 16 - Recognizing Functional Groups

    Lec 17 - Reaction Analogies and Carbonyl Reactivity

    Lec 18 - Amide, Carboxylic Acid and Alkyl Lithium

    Lec 19 - Oxygen and the Chemical Revolution (Beginning to 1789)

    Lec 20 - Rise of the Atomic Theory (1790-1805)

    Lec 21 - Berzelius to Liebig and Wöhler (1805-1832)

    Lec 22 - Radical and Type Theories (1832-1850)

    Lec 23 - Valence Theory and Constitutional Structure (1858)

    Lec 24 - Determining Chemical Structure by Isomer Counting (1869)

    Lec 25 - Models in 3D Space (1869-1877); Optical Isomers

    Lec 26 - Van't Hoff's Tetrahedral Carbon and Chirality

    Lec 27 - Communicating Molecular Structure in Diagrams and Words

    Lec 28 - Stereochemical Nomenclature; Racemization and Resolution

    Lec 29 - Preparing Single Enantiomers and the Mechanism of Optical Rotation

    Lec 30 - Esomeprazole as an Example of Drug Testing and Usage

    Lec 32 - Stereotopicity and Baeyer Strain Theory

    Lec 33 - Conformational Energy and Molecular Mechanics

    Lec 34 - Sharpless Oxidation Catalysts and the Conformation of Cycloalkanes

    Lec 35 - Understanding Molecular Structure and Energy through Standard Bonds

    Lec 36 - Bond Energies, the Boltzmann Factor and Entropy

    Lec Last - Potential Energy Surfaces, Transition State Theory and Reaction Mechanism