This In3D animation highlights the inital steps of RNA transscription by the RNA-dependent RNA polymerase from reovirus. In this animation you will observe several stages of transcription initiatio...(more)
This In3D animation highlights the inital steps of RNA transscription by the RNA-dependent RNA polymerase from reovirus. In this animation you will observe several stages of transcription initiation.
Beginning with a quick orientation of the enzyme itself, the viewer is then shown the capped RNA template that will later be used for initiation of transcription. The capped RNA binds in a special cleft on the enxyme surface. Following binding, the 3'-end of the RNA is fed into the enzyme actve site, where stranscription initiation occurs. Transcription begins with the formation of a pppGpG dimer (shown). Following formation of the dimer elongation comenses ielding full length RNA of the opposite polarity.
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