Actin Polymerization
Actin Polymerization. Actin polymerization and depolymerization is necessary in chemotaxis and cytokinesis. Nucleating factors are necessary to stimulate actin polymerization. One such nucleating factor is the ARP complex which acts as a barbed end of actin in its shape to stimulate the nucleation of G-actin (or monomeric actin). The ARP complex can also bind to actin filaments at 70 degrees to form new actin branches off of existing actin filaments. Also, actin filaments themselves bind ATP, and hydrolysis of this ATP stimulates destabilization of the polymer. Text Reff: Wikipedia
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actin polymerization
Added: March 26, 2009, 5:50 pm
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Actin Polymerization Model for Spire andFormin
Spire and formin - The formin cappucino binds to Spire's KIND domain. While bound to Spire, cappucino is unable to act as an actin nucleator, but does not inhibit Spire's nucleation activity.
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spire
Added: December 19, 2007, 1:14 am
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Spire mechanism
Spire mechanism - The protein Spire contains 4 WH2 domains which are each able to bind an actin monomer. A conformational change in linker 3 is thought to catalyze the formation of an actin nucleus.
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spire
Added: December 19, 2007, 1:13 am
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